解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt355
更新日期:2014-03-01 00:00:00
abstract::Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt349
更新日期:2014-03-01 00:00:00
abstract::CXCL5 is a member of the CXC-type chemokine family that may play a role in carcinogenesis and cancer progression. This study investigates the biological function and clinical significance of CXCL5 in intrahepatic cholangiocarcinoma (ICC). We demonstrated that CXCL5 was overexpressed in ICC cell lines and tumor samples...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt397
更新日期:2014-03-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Despite progress in developing chemotherapeutics for the treatment of NSCLC, primary and secondary resistance limits therapeutic success. NSCLC cells exhibit multiple mutations in the epidermal growth factor receptor (EGFR), which c...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt365
更新日期:2014-03-01 00:00:00
abstract::Despite advances in detection and treatment for breast cancer (BC), recurrence and death rates remain unacceptably high. Therefore, more convenient diagnostic and prognostic methods still required to optimize treatments among the patients. Here, we report the clinical significance of the serum cathepsin E (CatE) activ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt373
更新日期:2014-03-01 00:00:00
abstract::MicroRNA deregulation and pathway alterations have been implicated in nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer widely prevalent in Southern China. In this study, we report that miR-9 is commonly downregulated in NPC specimens and NPC cell lines with important functional consequences. The...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt354
更新日期:2014-03-01 00:00:00
abstract::Observational studies and animal evidence suggest an association between coffee consumption and the risk of prostate cancer. However, the results are inconsistent. We evaluated the association by conducting a meta-analysis of prospective cohort studies. PubMed and Embase were searched through June 2013 to identify stu...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgt482
更新日期:2014-02-01 00:00:00
abstract::Colorectal cancer (CRC) displays a predilection for metastasis to liver. Although stromal cell-derived factor-1 (SDF-1)/CXCR4 plays an important role in the liver metastasis, the molecular mechanism still remains obscure. We previously reported that integrin αvβ6 was implicated in the progression of CRC. However, no d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt331
更新日期:2014-02-01 00:00:00
abstract:UNLABELLED:Neurotrophic factors possess an emerging role in the pathophysiology of several gastrointestinal disorders, regulating innervation, pain sensation and disease-associated neuroplasticity. Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-der...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt312
更新日期:2014-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are endogenous non-coding RNAs, which play an essential role in the regulation of gene expression during carcinogenesis. The role of miRNAs in breast cancer has been thoroughly investigated, and although many miRNAs are identified as cancer related, little is known about their involvement in benign ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt333
更新日期:2014-01-01 00:00:00
abstract::The identification of primary molecular targets of cancer-preventive phytochemicals is essential for a comprehensive understanding of their mechanism of action. In the present study, we investigated the chemopreventive effects and molecular targets of acacetin, a flavonoid found in Robinia p seudoacacia, also known as...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt266
更新日期:2014-01-01 00:00:00
abstract::DNA-demethylating agents activate tumor suppressor genes that are silenced by DNA methylation in cancer and are therefore emerging as a novel approach to cancer therapy. 5-azacytidine (VIDAZA), the first representative of this class of drugs was approved for treatment of myelodysplastic syndromes and is currently bein...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt284
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt314
更新日期:2014-01-01 00:00:00
abstract::Wnt signaling plays a central role in mammary stem cell (MaSC) homeostasis and in breast cancer. In particular, epigenetic alterations at different members of the Wnt pathway have been identified among triple-negative, basal-like breast cancers. Previously, we developed a mouse model for metaplastic breast adenocarcin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt279
更新日期:2014-01-01 00:00:00
abstract::The antitumorigenic activities of polyphenols such as ellagitannins and anthocyanins in pomegranate (Punica granatum L.) have been previously studied where cytotoxic, anti-inflammatory and antioxidant effects were evident in various cancer models. The objective of this study was to investigate the role of miR-126/vasc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt295
更新日期:2013-12-01 00:00:00
abstract::Alternative splicing regulators have emerged as new players in cancer development, modulating the activities of many tumor suppressors and oncogenes and regulating the signaling pathways. However, little is known about the mechanisms by which these oncogenic splicing factors lead to cellular transformation. We have sh...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt247
更新日期:2013-11-01 00:00:00
abstract::Telomerase activity in cancer cells is dependent on the transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of human telomerase. We have shown previously that HTLV-1 basic leucine zipper (HBZ), a viral regulatory protein encoded by the human retrovirus,...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt221
更新日期:2013-11-01 00:00:00
abstract::It has been demonstrated that nuclear factor-kappa B (NF-κB), which is overactivated in hepatocellular carcinoma (HCC), plays important roles in the development of HCC. Recently, a group of dysregulated micro RNAs were reported to be involved in HCC progression. Further understanding of micro RNA-mediated regulation o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt206
更新日期:2013-11-01 00:00:00
abstract::CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt181
更新日期:2013-10-01 00:00:00
abstract::Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown clinical results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound paclitaxel, may carry superior distribution properties into the tumor micr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt227
更新日期:2013-10-01 00:00:00
abstract::Chemotherapeutic agents have been the mainstay of cancer therapy for years. However, their effectiveness has been limited by toxicities they impart on normal cells. Staurosporine (ST) has been shown to arrest normal, but not breast cancer, cells in G1. Therefore, ST may become a chemoprotective agent, arresting normal...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt186
更新日期:2013-10-01 00:00:00
abstract::Insulin-like growth factor-II (IGF-II) may be a prognostic marker in ovarian cancer, and its intronic single nucleotide polymorphism (SNP) rs4320932 has been associated with risk of the disease. We determined whether rs4320932 is associated with IGF-II expression and patient survival in ovarian cancer, and explored wh...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt168
更新日期:2013-09-01 00:00:00
abstract::The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impac...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgt163
更新日期:2013-09-01 00:00:00
abstract::Pardaxin, an antimicrobial peptide secreted by the Red Sea flatfish Pardachirus marmoratus, inhibits proliferation and induces apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are only partially understood at present. In this study, we used proteomic approaches and network reconstruct...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt130
更新日期:2013-08-01 00:00:00
abstract::Recent genome-wide association studies have identified 15 single nucleotide polymorphisms (SNPs) associated with non-Hodgkin lymphoma (NHL) and its subtypes. Because the incidence and subtype portion of NHL between the Chinese population and Caucasian populations are substantially different, we assessed the associatio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt082
更新日期:2013-07-01 00:00:00
abstract::The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in viv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt097
更新日期:2013-07-01 00:00:00
abstract::The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene tran...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgt127
更新日期:2013-07-01 00:00:00
abstract::Bone metastasis in patient with advanced-stage prostate cancer, the most commonly diagnosed malignancy in Western countries, increases the risk of intractable bone pain. The nephroblastoma overexpressed (NOV/CCN3) gene, a member of the CCN gene family, is responsible for the secretion of CCN3, a matrix-associated prot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt103
更新日期:2013-07-01 00:00:00
abstract::Medulloblastoma (MB) cells arise from granule neuron precursors (GNPs) that have lost growth control. During normal development, GNPs divide in response to Sonic hedgehog (SHH), a ligand that binds to the patched (PTCH) receptor on GNPs. If one copy of the Ptch gene is lost, as in human Gorlin's syndrome and in Ptch(+...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt041
更新日期:2013-06-01 00:00:00
abstract::The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascent...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgt111
更新日期:2013-06-01 00:00:00
abstract::In this study, primary murine prostate cancer (PCa) cells were derived using the well-established TRAMP model. These PCa cells were treated with the histone deacetylase inhibitor, valproic acid (VPA), and we demonstrated that VPA treatment has an antimigrative, antiinvasive and antiproliferative effect on PCa cells. U...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt019
更新日期:2013-05-01 00:00:00
abstract::In China, esophageal cancer is the fourth leading cause of cancer death where essentially all cases are histologically esophageal squamous cell carcinoma (ESCC), in contrast to esophageal adenocarcinoma in the West. Globally, ESCC is 2.4 times more common among men than women and recently it has been suggested that se...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt030
更新日期:2013-05-01 00:00:00
abstract::The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th and 12th, respectively, in human cancers diagnosed worldwide in 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) and their direct targets in OSCC, we performed methylation-based screening for 43 miRNA...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs376
更新日期:2013-03-01 00:00:00
abstract::MicroRNAs (miRNAs or miR) have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-124 was reported to be attenuated in several tumors, such as glioma, medulloblastoma and hepatocellular carcinoma. However, its role in cancer remains greatly elusive. In this study, we show ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs383
更新日期:2013-03-01 00:00:00
abstract::Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions in the body. Presently, there are markedly conflicting findings in the literature regarding NO and its role in carcinogenesis and tumor progression. NO has been shown to have dichotomous effects on cellular proliferation,...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgt034
更新日期:2013-03-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with significantly high prevalence in Southern China. Unlike other head and neck cancers, mutations or deletions of tumor suppressor genes in NPC are not common. Recently, downregulation of tumor suppressor genes expression by microRNA (miRNA) is increas...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs346
更新日期:2013-02-01 00:00:00
abstract::Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley and onions, has been reported to possess anticarcinogenic effects. However, the direct molecular target of apigenin and its chemopreventive effect on ultraviolet (UV)-induced skin inflammation are not understood fully. Herein, we examin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs358
更新日期:2013-02-01 00:00:00
abstract::We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs351
更新日期:2013-02-01 00:00:00
abstract::Deregulated microRNAs (miRNAs) and their roles in cancer development have attracted much attention. Two miRNAs, miR-15a and miR-16, which act as putative tumor suppressor by targeting the oncogene BCL2, have been implicated in cell cycle, apoptosis and proliferation. In this study, we investigated the possible role ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs333
更新日期:2013-02-01 00:00:00
abstract::Neuroblastic tumors (NTs) include the neuroblastomas, ganglioneuroblastomas and ganglioneuromas. We have reported previously that the calcium-sensing receptor is expressed in differentiated, favorable NTs but almost undetectable in unfavorable neuroblastomas. We have now detected hypermethylation of a particular regio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs338
更新日期:2013-02-01 00:00:00